Napsin A（天冬氨酸蛋白酶4）

廣州健侖生物科技有限公司

Napsin 是一種胃酶樣天門(mén)冬氨酸蛋白酶，分為Napsin A 和Napsin B兩種，Napsin A 是一個(gè)分子量約為38kDa 的單鏈蛋白，在肺、腎中存在高表達(dá)，在脾臟中低表達(dá)。Napsin A 在II 型肺泡和肺腺癌中表達(dá)，其在肺腺癌特異性的高表達(dá)有助于區(qū)別肺腺癌和其他來(lái)源的腺癌以及其他類(lèi)型的肺癌。

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Napsin A（天冬氨酸蛋白酶4）

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿

適用組織：石蠟/冰凍

陽(yáng)性對(duì)照：肺腺癌

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：30-60min

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【公司名稱(chēng)】 廣州健侖生物科技有限公司
【市場(chǎng)部】     歐

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

更有意思的是，研究人員發(fā)現(xiàn)，缺失人類(lèi)等量Nox2的病人往往會(huì)遭受感染的復(fù)發(fā)及炎性的擴(kuò)展，這種障礙名為慢性肉芽腫病;本文研究揭示了一種引發(fā)病人患慢性肉芽腫病的原因或許是因?yàn)闄C(jī)體巨噬細(xì)胞并不能遷移到炎性位點(diǎn)來(lái)誘導(dǎo)中性粒細(xì)胞的反向遷移活動(dòng)及炎性的恢復(fù)。
近年來(lái)，纖毛這種顯微尺寸的、生物細(xì)胞的觸須樣延伸物已經(jīng)擺脫了相對(duì)朦朧的狀態(tài)，如今被認(rèn)為對(duì)于理解許多人類(lèi)疾病具有重要性。在12月的《生物科學(xué)》(Bioscience)雜志的一篇論文中，美國(guó)馬薩諸塞大學(xué)醫(yī)學(xué)院的george B. Witman與Salem州立大學(xué)的Jason M. Brown描述了近來(lái)關(guān)于纖毛相關(guān)疾病的發(fā)現(xiàn)，并且強(qiáng)調(diào)了可能對(duì)于纖毛疾病的系統(tǒng)研究有用的“模式”物種。
纖毛執(zhí)行一大批功能，包括細(xì)胞信號(hào)傳導(dǎo)的主角作用。能動(dòng)的纖毛能夠搖擺，從而移動(dòng)體內(nèi)的液體，包括大腦的腦脊髓液。在人類(lèi)中間，纖毛見(jiàn)于人類(lèi)的幾乎所有細(xì)胞。由于這種情況，纖毛疾病常常被稱(chēng)為對(duì)一些類(lèi)型的組織有廣泛多樣的效應(yīng)的綜合征。例如，窒息性胸廓發(fā)育不良這種纖毛疾病涉及短得不正常的肋骨的發(fā)育，還伴隨著短的四肢，有時(shí)候還伴隨著多余的手指的發(fā)育。

Napsin is a pepsin-like aspartic proteinase, which is divided into two types: Napsin A and Napsin B. Napsin A is a single chain protein with a molecular weight of about 38 kDa. It is highly expressed in the lung and kidney and low in the spleen . Napsin A is expressed in type II alveoli and lung adenocarcinomas and its specific high expression in lung adenocarcinomas helps differentiate lung adenocarcinoma from other adenocarcinomas and other types of lung cancer.

More interestingly, the researchers found that patients who lack the equivalent amount of Nox2 in humans often suffer from recurrent and inflammatory spread of the infection called chronic granulomatous disease; this study reveals a disorder that causes chronic granulomatosis The reason may be due to the fact that macrophages do not migrate to inflammatory sites to induce neutrophil reverse migration and inflammatory recovery.
In recent years, the microscopic size of the cilia-like, tentacle-like extension of biological cells has escaped its relatively obscure status and is now considered to be of importance in understanding many human diseases. In a December paper in the journal Bioscience, george B. Witman of the University of Massachusetts Medical School and Jason M. Brown of Salem State University described recent findings on cilia-related diseases and highlighted Useful "model" species may be useful for systematic research on cilia disease.
Cilia performs a number of functions, including the protagonist of cell signaling. Active cilia can sway to move fluids in the body, including the cerebrospinal fluid of the brain. Among humans, cilia is found in almost all human cells. Because of this condition, cilia disease is often referred to as a syndrome that has a wide variety of effects on some types of tissues. For example, asphyxiated thoracic hypoplasia, a ciliary disease that involves the development of unusually short ribs, is accompanied by short limbs and occasionally with excess finger development.