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Cyclin D1(周期素D1)兔單克隆抗體
廣州健侖生物科技有限公司
CyclinD1(PRAD-1或bcl-1)是一個(gè)重要的細(xì)胞周期調(diào)節(jié)因子，功能與細(xì)胞周期素依賴激酶4或細(xì)胞周期素依賴激酶6 磷酸化Rb蛋白有關(guān)。它是一個(gè)有爭(zhēng)議的原癌基因,在許多人類腫瘤包括套細(xì)胞淋巴瘤中表達(dá)。
簡(jiǎn)單來(lái)講，細(xì)胞周期可以分為四個(gè)階段：G0/G1、S、G2及M。G1和G2期是細(xì)胞生長(zhǎng)期；S期是細(xì)胞將細(xì)胞核內(nèi)的染色體復(fù)制的時(shí)期；M期是細(xì)胞進(jìn)行有絲分裂(mitosis)或減數(shù)分裂(meiosis)的時(shí)期。
在各個(gè)時(shí)期各有不同的周期素所調(diào)控著，不同的周期素在細(xì)胞周期的不同階段發(fā)生作用。細(xì)胞周期的主要周期素有：cyclin A, cyclin B, cyclin D及cyclin E。在G1期→S期調(diào)控蛋白為細(xì)胞周期蛋白D1(cyclin D1)以及細(xì)胞周期蛋白E(cyclin E)，s期→G2期調(diào)控蛋白為細(xì)胞周期蛋白A(cyclin A)，G2期→M期調(diào)控蛋白為細(xì)胞周期蛋白B(cyclin B)。
每一個(gè)周期素都有一個(gè)共同位叫cyclin box。cyclin box的功能是激活一種叫周期素激酶(cyclin-dependent kinase; CDK)。
不同的周期素激酶在細(xì)胞周期的不同階段發(fā)生作用。例如：cyclin D激活CDK4或CDK6掌控G1期的細(xì)胞生長(zhǎng)；cyclin A及cyclin E激活CDK2調(diào)控染色體復(fù)制；cyclin A及cyclin B激活CDK1調(diào)控有絲分裂和減數(shù)分裂。有趣的是，有些周期素雖然擁有cyclin box但它們沒有可激活的CDK：例如cyclin F, cyclin I以及cyclin G。而且cyclin I并沒有細(xì)胞周期的調(diào)控功能，它主要作用在神經(jīng)細(xì)胞上。
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Cyclin D1(周期素D1)兔單克隆抗體
【產(chǎn)品介紹】
細(xì)胞定位：細(xì)胞核
克隆號(hào)：SP4
同型：IgG
適用組織：石蠟/冰凍
陽(yáng)性對(duì)照：套細(xì)胞淋巴瘤
抗原修復(fù)：熱修復(fù)（EDTA）
抗體孵育時(shí)間：30-60min
| 產(chǎn)品編號(hào) | 抗體名稱 | 克隆型別 |
| OB071 | CD8(T細(xì)胞) | SP16 |
| OB072 | CD99(尤文氏肉瘤標(biāo)記) | EPR3097Y |
| OB073 | CDX-2(腸道特異性轉(zhuǎn)錄因子) | EPR2764Y |
| OB074 | CEA 癌胚抗原 | polyclonal |
| OB075 | CEA(癌胚抗原) | CEA31 |
| OB076 | Chromogranin A(嗜鉻素A) | LK2H10 |
| OB077 | CMV(巨細(xì)胞病毒) | 8B1.2,1G5.2&2D4.2 |
| OB078 | c-myc（原癌基因蛋白） | EP121 |
| OB079 | Collagen Type Ⅳ(Ⅳ型膠原) | CIV22 |
| OB080 | COX-2(環(huán)氧合酶2) | SP21 |
| OB081 | Cyclin D1(周期素D1) | SP4 |
| OB082 | Cytokeratin (34betaE12)(細(xì)胞角蛋白(34βE12)) | 34βE12 |
| OB083 | Cytokeratin 14(細(xì)胞角蛋白14) | LL002 |
| OB084 | Cytokeratin 17(細(xì)胞角蛋白17) | Ks17.E3 |
| OB085 | Cytokeratin 19(細(xì)胞角蛋白19) | A53-B/A2.26 |
| OB086 | Cytokeratin 20(細(xì)胞角蛋白20) | Ks20.8 |
Cyclin D1(周期素D1)兔單克隆抗體
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【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】 歐
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【騰訊 】
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室
CyclinD1 (PRAD-1 or bcl-1) is an important cell cycle regulator that functions in conjunction with cyclin-dependent kinase 4 or cyclin-dependent kinase 6 phosphorylation of Rb protein. It is a controversial oncogene that is expressed in many human tumors, including mantle cell lymphoma.
In simple terms, the cell cycle can be divided into four stages: G0 / G1, S, G2 and M. The G1 and G2 phases are the cell growth phase; the S phase is the period in which the cells replicate the chromosomes in the nucleus; and the M phase is the period in which the cells undergo mitosis or meiosis.
In different periods of different cyclins regulation, different cyclins in the different stages of the cell cycle play a role. The main cell cycle cycle are: cyclin A, cyclin B, cyclin D and cyclin E. In the G1 phase → S phase, the regulatory proteins are cyclin D1 and cyclin E, and the s-phase → G2-phase regulatory proteins are cyclin A, G2 → M phase regulation The protein is cyclin B.
Every cyclotron has a common denominator called a cyclin box. The function of the cyclin box is to activate a cell cycle called cyclin-dependent kinase (CDK).
Different cyclin kinases act at different stages of the cell cycle. For example, cyclin D activates CDK4 or CDK6 to control G1 cell growth; cyclin A and cyclin E activate CDK2 to regulate chromosome replication; and cyclin A and cyclin B activate CDK1 to regulate mitosis and meiosis. Interestingly, although some cyclin have a cyclin box, they do not have an activatable CDK: cyclin F, cyclin I, and cyclin G, for example. And cyclin I does not have the cell cycle regulatory function, it mainly acts on nerve cells.
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