CD11c整合素α鏈蛋白（鼠單克隆抗體）

廣州健侖生物科技有限公司

蛋白酪氨酸激酶綜述；目前至少已有近六十種分屬20個(gè)家族的受體酪氨酸激；一、表皮生長因子受體(Epidermalgrov)；EGFRPE包括EGFR、ErbB2、ErbB4；單體形式存在，在結(jié)構(gòu)上由胞外區(qū)、跨膜區(qū)、胞內(nèi)區(qū)3；人的egfr基因定位于第7號(hào)染色體的短臂7p1；EGFR在許多上皮業(yè)源的腫瘤細(xì)胞中表達(dá)，如非小細(xì)；ErbB2，又名HER-2/neu，是E蛋白酪氨酸激酶綜述。
目前至少已有近六十種分屬20個(gè)家族的受體酪氨酸激酶被子識(shí)別。所有受體酷氨酸激酶都屬于I型膜蛋白，其分子具有相似的拓樸結(jié)構(gòu)：糖基化的胞外配體結(jié)合區(qū)，疏水的單次跨膜區(qū)，以及胞內(nèi)的酪氨酸激酶催化結(jié)構(gòu)域及調(diào)控序列。不同受體酪氨酸激酶結(jié)合，將導(dǎo)致受體發(fā)生三聚化，并進(jìn)一步使受體胞內(nèi)區(qū)特異的受體酪氨酸殘基發(fā)生自身磷酸化或交叉磷酸化，從而激活下游的信號(hào)轉(zhuǎn)導(dǎo)通路。許多腫瘤的發(fā)生、發(fā)展都與酪氨酸激酶的異常表達(dá)有著極其密切的。

我司還提供其它進(jìn)口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團(tuán)菌、化妝品檢測(cè)、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

歡迎咨詢

歡迎咨詢

【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿

克隆號(hào)：5D11

同型：IgG2a

適用組織：石蠟/冰凍

陽性對(duì)照：毛細(xì)胞白血病/骨髓/扁桃體

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時(shí)間：30-60min

CD11c整合素α鏈蛋白（鼠單克隆抗體）

弓形蟲病是由一種剛地弓形蟲（Toxoplasma gondii）引起的人和動(dòng)物的感染。弓形蟲屬于形體zui小、結(jié)構(gòu)簡(jiǎn)單的一類叫作原蟲的寄生蟲。貓和其他貓科動(dòng)物是弓形蟲的終宿主，它寄生在這些動(dòng)物的小腸上皮細(xì)胞內(nèi)，形成囊合子（許多文章稱作“囊合子”，不夠準(zhǔn)確）隨糞便排出，其他哺乳動(dòng)物和鳥吃進(jìn)去發(fā)生感染，在它們身體的組織內(nèi)發(fā)育成為包囊。囊合子和包囊是弓形蟲的不同發(fā)育階段。雖然弓形蟲并不“挑剔”，但是除了終宿主以外，在其他動(dòng)物體內(nèi)只能進(jìn)行無性繁殖，不能向外界散播它的后代。
弓形蟲屬頂端復(fù)合物亞門(subphylum Apicomplexa)，孢子蟲綱(clss sporozoasida)，真球蟲目(order Eucoccidiorida)，細(xì)胞內(nèi)寄生性原蟲，其生活史中出現(xiàn)5種形態(tài)，即滋養(yǎng)體(速殖子，tachyzoite);包囊(可長期存活于組織內(nèi))，呈圓形或橢圓形，直徑10～200μm，破裂后可釋出緩殖子，(bradyzoite);裂殖體;配子體和囊合子(oocyst)，前3期為無性生殖，后2期為有性生弓形蟲生活史的完成需雙宿主：在終宿主(貓與貓科動(dòng)物)體內(nèi)，上述5種形成俱存;在中間宿主(包括禽類，哺乳類動(dòng)物和人)體內(nèi)則僅有無性生殖而無有性生殖，無性生殖常可造成全身感染，有性生殖僅在終宿主腸粘膜上皮細(xì)胞內(nèi)發(fā)育造成局部感染，囊合子由貓糞排出，發(fā)育成熟后含二個(gè)孢子囊(sporocyst)，各含4個(gè)子孢子(sporozoite)，在電鏡下子孢子的結(jié)構(gòu)與滋養(yǎng)體相似，囊合子被貓?zhí)蚴澈螅谄淠c中，囊內(nèi)的子孢子逸出，侵入回腸末端粘膜上皮細(xì)胞進(jìn)行裂體增殖，細(xì)胞破裂后裂殖子逸出，侵入附近的細(xì)胞，繼續(xù)裂體增殖，部分則發(fā)育為雌雄配子體，進(jìn)行配子增殖，形成囊合子，后者落入腸腔，在適宜溫度(24℃)和濕度環(huán)境中，約經(jīng)2～4天發(fā)育成熟，抵抗力強(qiáng)，可存活1年以上，如被中間宿主吞入，則進(jìn)入小腸后子孢子穿過腸壁，隨血液或淋巴循環(huán)播散全身各組織細(xì)胞內(nèi)以縱二分裂法(endodyogeny)進(jìn)行增殖，在細(xì)胞內(nèi)可形成多個(gè)蟲體的集合體，稱假包囊(pseudocyst)，囊內(nèi)的個(gè)體即滋體或速殖子，為急性期病例的常見形態(tài)，宿主細(xì)胞破裂后，滋養(yǎng)體散出再侵犯其他組織細(xì)胞，如此反復(fù)增殖，可致宿主死亡，但更多見的情況是宿主產(chǎn)生免疫力，使原蟲繁殖減慢，其外有囊壁形成，稱包囊，囊內(nèi)原蟲稱緩殖子，包囊在中間宿主體內(nèi)可存在數(shù)月，數(shù)年，甚至終生(呈陷抗原抗體染狀態(tài))。

CD11c整合素α鏈蛋白（鼠單克隆抗體）

我司還提供其它進(jìn)口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團(tuán)菌、化妝品檢測(cè)、食品安全檢測(cè)等試劑盒以及日本生研細(xì)菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

想了解更多的產(chǎn)品及服務(wù)請(qǐng)掃描下方二維碼：

【公司名稱】 廣州健侖生物科技有限公司
【市場(chǎng)部】    楊永漢

【】 
【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號(hào)二期2幢101-103室

Toxoplasmosis is a human and animal infection caused by a Toxoplasma gondii. Toxoplasma belonging to the smallest form, simple structure of a class called protozoan parasites. Cats and other cats are the ultimate hosts of toxoplasma parasites in the intestinal epithelial cells of these animals, forming zygotes (many articles called "zygotes" that are not accurate enough) to be excreted with feces and other mammals and birds Infection occurs and develops into cysts within the tissues of their body. Cystic zygotes and cysts are different stages of development of Toxoplasma. Toxoplasma gondii is not "picky", but except the final host, it can only do asexual reproduction in other animals and can not spread its offspring to the outside world.
Toxoplasma subphylum apex (subphylum Apicomplexa), Sporididae (Clss sporozoasida), Order Eucoccidiorida order, intracellular parasitic protozoa, the life cycle of its five forms, the trophozoites (speed Tachyzoite); cysts (long-term survival in the organization), was round or oval, diameter 10 ~ 200μm, release after rupture of bradyzoites (bradyzoite); schizonts; gametocytes and capsule zygote (oocyst), the first three stages of asexual reproduction, the latter two stages of sexual life to be required to complete the life cycle of Toxoplasma require dual-host: in the final host (cats and cats) body, the above five kinds of formation of co-exist; in the intermediate host (Including poultry, mammals and people) in the body only asexual reproduction without sexual reproduction, asexual reproduction can often cause systemic infection, sexual reproduction only in the development of end-host intestinal mucosal epithelial cells caused by local infection, Cat faeces are excreted, and after maturation they contain two sporozoites, each containing four sporozoites. The structure of the sporozoites is similar to that of trophozoites under electron microscopy. After the zygotes are licked by cats, Sporozoites within the escape, invasion back Intestinal end mucosal epithelial cells to split proliferation, cell rupture after the merozoites escape, invade the nearby cells continue to split body proliferation, some are developed into male and female gametophytes, gamete proliferation, the formation of cystic zygotes, which fall into the intestine , In the appropriate temperature (24 ℃) and humidity environment, about 2 to 4 days mature, strong resistance, can survive for more than 1 year, such as being swallowed by the intermediate host, enter the small intestine after the sporozoites through the intestinal wall, With the blood or lymphatic circulation spread throughout the body cells in the longitudinal division method (endodyogeny) proliferation in the cell can form a collection of multiple parasites, said the pseudocyst (pseudocyst), the individual capsule that is AIDS Body or tachyzoites, the common form of acute cases, the host cell rupture, trophozoites shed another violated other tissue cells, so repeated proliferation, can cause death of the host, but more often the case is the host immune system, The protozoan reproduction slowed, the outer wall of the formation of cysts, said cysts, cysts known as the protozoa bursa, cysts in the intermediate host can exist in the body for several months, years, or even life-long (antigen-stained antibody state).