Calretinin鈣視網(wǎng)膜蛋白（鼠單克隆抗體）

廣州健侖生物科技有限公司

鈣調(diào)蛋白是細(xì)胞第二信使系統(tǒng)的重要成分，在Ca信號系統(tǒng)傳導(dǎo)中起著關(guān)鍵的作用，調(diào)控生理代謝及基因表達(dá)，控制細(xì)胞正常的生長和發(fā)育。鈣調(diào)蛋白作為第二信使在植物信號轉(zhuǎn)導(dǎo)中的作用一直是植物生理、細(xì)胞生物學(xué)和發(fā)育生物學(xué)研究的熱點(diǎn)。Ca/CaM是有機(jī)體進(jìn)化過程中zui保守的信號轉(zhuǎn)導(dǎo)級聯(lián)反應(yīng)系統(tǒng)，這一信號途徑廣泛存在于真核細(xì)胞中，并在各種細(xì)胞活動如脅迫反應(yīng)和細(xì)胞增殖中起調(diào)節(jié)作用。這種Ca/CaM信號系統(tǒng)存在的普遍性和保守性·對鈣調(diào)蛋白的研究可以使我們可以更好地利用其功能為人類服務(wù)。

我司還提供其它進(jìn)口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團(tuán)菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細(xì)菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

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【產(chǎn)品介紹】

細(xì)胞定位：細(xì)胞漿/細(xì)胞核

克隆號：2E7

同型：IgG

適用組織：石蠟/冰凍

陽性對照：間皮瘤/闌尾(神經(jīng)組織)/腎上腺皮質(zhì)

抗原修復(fù)：熱修復(fù)（EDTA）

抗體孵育時間：30-60min

Calretinin鈣視網(wǎng)膜蛋白（鼠單克隆抗體）

致病性與免疫性
與致病性有關(guān)的物質(zhì)除莢膜、細(xì)胞壁脂多糖外，尚有多種生物學(xué)活性因子。百日咳外毒素是主要的致病因子，能誘發(fā)機(jī)體的持久免疫力，并有多種生物活性，如提高小鼠對組織胺、5～羥色胺和敏感性，促進(jìn)白細(xì)胞增多，抑制巨噬細(xì)胞功能，損傷呼吸道纖毛上皮細(xì)胞導(dǎo)致陣發(fā)性痙攣咳嗽等。細(xì)菌破裂后還能在宿主細(xì)胞漿中查到一種熱不穩(wěn)定性毒素和其他幾種抗原成份，可引起纖毛上皮細(xì)胞炎癥和壞死。
百日咳桿菌引起人類百日咳。病人，尤其是癥狀輕微的非典型病人是重要的傳染源。主要經(jīng)飛沫傳播。易感兒童接觸病人后發(fā)病率接近90%，一歲以下患兒病死率高。百日咳潛伏期1～2周。發(fā)病早期（卡他期）僅有輕度咳嗽。細(xì)菌此時在氣管和支氣管粘膜上大量繁殖并隨飛沫排出，傳染性zui大。1～2周后出現(xiàn)陣發(fā)性痙攣性咳嗽（痙攣期），這時細(xì)菌釋放毒素，導(dǎo)致粘膜上皮細(xì)胞纖毛運(yùn)動失調(diào)，大量粘稠分泌物不能排出，刺激粘膜中的感受器產(chǎn)生強(qiáng)烈痙咳，呈現(xiàn)出特殊的高音調(diào)雞鳴樣吼聲。形成的粘液栓子還能堵塞小支氣管導(dǎo)致肺不張和呼吸困難、紫紺。此外可伴有嘔吐、驚厥。4～6周后逐漸轉(zhuǎn)入恢復(fù)期，陣咳減輕，趨向*，但有1～10%病人易繼發(fā)溶血性鏈球菌、流感桿菌等的感染。本病病程較長，故名百日咳。在致病過程中，百日咳桿菌始終在纖毛上皮細(xì)胞表面，并不入血。
感染百日咳后可出現(xiàn)多種特異性抗體，免疫力較為持久。僅少數(shù)病人可再次感染，再發(fā)的病情亦較輕。粘膜局部的分泌型lgA具有阻止細(xì)菌粘附氣管粘膜細(xì)胞纖毛的作用，其抗感染作用比血清中的抗體更重要。細(xì)胞免疫在百日咳桿菌感染中的作用還不甚明了。
微生物學(xué)診斷編輯
以分離培養(yǎng)為主，卡他期分離陽性率可達(dá)91.5%,而恢復(fù)期僅有約26%。標(biāo)本采用鼻咽試子或咳皿法，在鮑～金工培養(yǎng)平板上孵育，根據(jù)菌落形態(tài)，涂片染色鏡檢作出初步診斷。確診可用分離菌與Ⅰ相免疫血清作血清玻片凝集或免疫熒光染色。
防治原則編輯
隔離病人，隔離期自發(fā)病起七周。

Calretinin

我司還提供其它進(jìn)口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團(tuán)菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細(xì)菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

想了解更多的產(chǎn)品及服務(wù)請掃描下方二維碼：

【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

Pathogenicity and immunity
Pathogenic substances in addition to capsular, cell wall lipopolysaccharide, there are a variety of biological activity factor. Pertussis toxin is the main virulence factor that can induce the body's long-lasting immunity and a variety of biological activity, such as mice to histamine, serotonin and sensitivity, and promote leukocytosis, inhibition of macrophage function, Damage to the respiratory ciliated epithelial cells leads to paroxysmal spasms and coughing. Bacteria can also be found in the host cell after the rupture of a thermotolerant toxins and several other antigen components, can cause inflammation and necrosis of ciliated epithelial cells.
Bordela pertussis causes human pertussis. Patients, especially atypical patients with mild symptoms, are an important source of infection. Mainly by the droplets spread. The susceptibility of children to contact with patients after the incidence of nearly 90% of children under one year of high mortality. Pertussis incubation period of 1 to 2 weeks. Early onset (catarrhal) only mild cough. Bacteria at this time in the trachea and bronchial mucosa multiply and discharge with the droplets, the most contagious. 1 to 2 weeks after the occurrence of paroxysmal spasmodic cough (spasm), when the bacteria release toxins, mucosal epithelial cells lead to cilia movement disorder, a large number of viscous secretions can not be discharged to stimulate the mucosa of the receptors produce strong spasmodic cough, showing A special high-pitched cock-like roar. The formation of mucus plug can also block the small bronchial aectasis and breathing difficulties, cyanosis. In addition can be associated with vomiting, convulsions. 4 to 6 weeks after the gradual transfer to the recovery period, cough relieve, tend to heal, but 1 to 10% of patients susceptible to secondary hemolytic streptococcus, influenza bacilli and other infections. The longer course of the disease, hence the name whooping cough. During the course of the disease, Bordela pertussis is always on the surface of ciliated epithelial cells and does not bleed.
Infection with pertussis can appear a variety of specific antibodies, the immunity is more lasting. Only a small number of patients can be infected again, the recurrence of the disease is also lighter. Local secretion of lgA mucosal membrane to prevent bacterial adhesion of tracheal mucilage role in the role of anti-infection than serum antibodies is more important. The role of cellular immunity in B. pertussis infection is not clear.
Microbiology diagnostic editor
In isolation and culture, the positive rate of catarrhal separation up to 91.5%, while the recovery period of only about 26%. Specimens using nasopharyngeal or cough dish method, in the Bao ~ metalworking culture plate incubation, according to colony morphology, smear microscopy to make a preliminary diagnosis. Confirmed available isolates and phase I serum for serum slide agglutination or immunofluorescence staining.
Prevention principles editor
Isolation of patients, isolated from the onset of seven weeks.