AR雄激素受體（鼠單克隆抗體）

廣州健侖生物科技有限公司

雄激素中zui主要的形式為睪酮，雄激素在體內(nèi)起著重要的作用。除了與生植相關外，還具有保持體內(nèi)激素平衡；刺激蛋白質(zhì)合成代謝，促進氮沉積和增加肌纖維的數(shù)量和厚度等。通過對青春期前的豬（體重約為15kg）和青春期的豬（體重約為74kg）分組試驗，結果表明公豬的飼料報酬率比去勢公豬高20%，用睪酮或二氫睪酮處理的去勢公豬，蛋白質(zhì)合成率顯著高于對照去勢公豬，蛋白質(zhì)降解率顯著低于對照去勢公豬（Mulvaney，1984）。James T等（1992）通過用去甲雄三烯醇酮乙酸鹽處理小公牛，結果發(fā)現(xiàn)經(jīng)處理的小公牛平均日增重高于對照小公牛（P<O.001）。Tarocco C等（1986）對63頭大白公豬從30到130kg活重進行表型檢測發(fā)現(xiàn)血液中睪酮濃度與背膘呈顯著相關。然而雄激素是通過與雄激素受體（Androgen Receptor-AR）結合而發(fā)揮其功能的，若無雄激素受體，則雄激素對組織無刺激反應（refractory）。雄激素受體是雄激素作用的中介物質(zhì)。許多年來歐美一些國家一直在研究雄激素受體基因。

我司還提供其它進口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

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【產(chǎn)品介紹】

細胞定位：細胞核

克隆號：AR441

同型：IgG1

適用組織：石蠟/冰凍

陽性對照：前列腺

抗原修復：熱修復（EDTA）

抗體孵育時間：60min

AR雄激素受體（鼠單克隆抗體）

3.并發(fā)癥的治療
在積極有效的滅滴靈或抗原抗體治療下，腸道并發(fā)癥可得到緩解。暴發(fā)型患者有細菌混合感染，應加用抗生素。大量腸出血可輸血。腸穿孔、腹膜炎等必須手術治療者，應在滅滴靈和抗生素治療下進行。
腸阿米巴病若及時治療預后良好。如并發(fā)腸出血、腸穿孔和彌漫性腹膜炎以及有肝、肺、腦部轉(zhuǎn)移性膿腫者，則預后較差。治療后糞檢原蟲應持續(xù)6個月左右，以便及早發(fā)現(xiàn)可能的復發(fā)。
4.診斷性治療
如臨床上高度懷疑而經(jīng)上述檢查仍不能確診時，可給予足量抗原抗體注射或口服安痢平、滅滴靈等治療，如效果明顯，亦可初步作出診斷。
預防
治療患者及攜帶包囊者，飲水須煮沸，不吃生菜，防止飲食被污染。防止蒼蠅孳生和滅蠅。檢查和治療從事飲食業(yè)的排包囊及慢性患者，平時注意飯前便后洗手等個人衛(wèi)生。
環(huán)瓜氨酸肽（cyclic citrullinated peptide，CCP）
瓜氨酸是類風濕病患者血清中抗絲聚蛋白相關抗體識別的主要組成性抗原決定簇成分。采用CCP為抗原基質(zhì)檢測類風濕患者血清中的抗CCP抗體， 具有較高的敏感性和*的特異性。有研究提示抗CCP參與了類風濕發(fā)病過程。除此之外，抗CCP抗體陽性的類患者更容易出現(xiàn)關節(jié)的骨質(zhì)損壞。因此，抗CCP抗體陽性者的愈后可能較差，應采取更積極的治療措施。
抗環(huán)瓜氨酸肽抗體是風濕自身抗體系統(tǒng)的一種，類風濕關節(jié)炎（RA）具有高特異性的瓜氨酸相關自身抗體系統(tǒng)包括AKA、APF、AFA、抗CCP抗體，這些抗體對早期RA診斷具有較好的特異性。這些指標越高患風濕的可能性也越大。
抗環(huán)瓜氨酸肽抗體（CCP）是環(huán)狀聚絲蛋白的多肽片段，是以IgG型為主的抗體，對類風濕性關節(jié)炎（RA）具有很好的敏感性和特異性，且抗CCP抗體陽性的RA病人骨破壞較抗CCP抗體陰性者嚴重。
類風濕性關節(jié)炎（rheumatoid arthritis,RA）是一種常見的慢性自身免疫性疾病。在*大約有1%的人罹患此病。RA能引起關節(jié)的疼痛、僵直及腫脹。在發(fā)病2年內(nèi)即可能出現(xiàn)不可逆的骨關節(jié)損傷，并可引起多種并發(fā)癥，如神經(jīng)系統(tǒng)疾病、心包炎、淋巴腺炎等。因此，及早診斷RA及給予緩解病情的藥物治療，對控制病情非常重要。1998年，國外，*報道的抗環(huán)瓜氨酸肽抗體（anti-cyclic cirullinated peptide antibodies,抗CCP抗體）的檢測，對RA具有較高的敏感性和特異性，是RA新的血清標志物。

我司還提供其它進口或國產(chǎn)試劑盒：登革熱、瘧疾、流感、A鏈球菌、合胞病毒、腮病毒、乙腦、寨卡、黃熱病、基孔肯雅熱、克錐蟲病、違禁品濫用、肺炎球菌、軍團菌、化妝品檢測、食品安全檢測等試劑盒以及日本生研細菌分型診斷血清、德國SiFin診斷血清、丹麥SSI診斷血清等產(chǎn)品。

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【公司名稱】 廣州健侖生物科技有限公司
【市場部】    楊永漢

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【騰訊  】 
【公司地址】 廣州清華科技園創(chuàng)新基地番禺石樓鎮(zhèn)創(chuàng)啟路63號二期2幢101-103室

3. Complications of treatment
In the active and effective metronidazole or antigen antibody treatment, intestinal complications can be eased. Outbreaks of patients with bacterial infection, antibiotics should be added. A large number of intestinal bleeding can be transfused. Intestinal perforation, peritonitis and other surgery must be treated with metronidazole and antibiotics.
If the timely treatment of intestinal amoebas disease prognosis is good. Such as intestinal bleeding, intestinal perforation and diffuse peritonitis and liver, lung, brain metastatic abscess, the prognosis is poor. After treatment stool protozoa should last about 6 months, in order to detect possible early detection of recurrence.
4. Diagnostic treatment
If the clinical suspicion is high and can not be confirmed by the above examination, sufficient antigen or antibody can be given or oral An Li Ping, metronidazole and other treatment, such as the effect is obvious, but also make a preliminary diagnosis.
prevention
Treatment of patients and patients with cysts, drinking water to be boiled, do not eat lettuce, to prevent food contamination. Prevent flies from breeding and flies. Inspection and treatment of the catering industry in the cysts and chronic patients, usually pay attention to personal hygiene before and after washing hands and so on.
Cyclic citrullinated peptide (CCP)
Citrulline is a major constitutive antigenic determinant recognized by anti-fibrin-related antibodies in the serum of rheumatoid patients. Using CCP as the antigen matrix to detect anti-CCP antibody in the serum of rheumatoid patients has high sensitivity and high specificity. Some studies suggest that anti-CCP is involved in the pathogenesis of rheumatoid arthritis. In addition, anti-CCP antibody-positive patients are more prone to joint bone damage. Therefore, anti-CCP antibody-positive patients may be worse after healing, should take more aggressive treatment.
Anti-cyclic citrullinated peptide antibody is a rheumatoid autoantibody system that has high specificity for rheumatoid arthritis (RA). Citrulline-related autoantibody systems include AKA, APF, AFA, anti-CCP, RA diagnosis has good specificity. The higher these indicators, the greater the risk of rheumatism.
Anti-cyclic citrullinated peptide antibody (CCP) is a polypeptide fragment of cyclic fibroin, which is an IgG-based antibody with good sensitivity and specificity for rheumatoid arthritis (RA) Anti-CCP positive RA patients with bone destruction than anti-CCP antibody negative were serious.
Rheumatoid arthritis (RA) is a common chronic autoimmune disease. About 1% of people in the world suffer from the disease. RA can cause joint pain, stiffness and swelling. Irreversible bone and joint damage may occur within 2 years of onset and may cause various complications such as nervous system diseases, pericarditis and lymphadenitis. Therefore, early diagnosis of RA and given to alleviate the condition of the drug treatment, the control of the disease is very important. In 1998, foreign countries, the first reported anti-cyclic citrullinated peptide antibodies (anti-CCP antibody) detection, RA has high sensitivity and specificity, is a new serum marker of RA.