泛素結合酶7相互作用蛋白5抗體

英文名稱 UBOX5
中文名稱 泛素結合酶7相互作用蛋白5抗體
別    名 UIP5; UIP-5; UIP 5; RING finger protein 37; RNF37; U-box domain containing 5; U-box domain-containing protein 5; UBCE7IP5; ubiquitin conjugating enzyme 7 interacting protein 5; UBOX5; RNF37_HUMAN.
 
說 明 書 0.2ml  
研究領域 細胞生物  免疫學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, 
產品應用 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 59kDa
細胞定位 細胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBOX5/RNF37
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產品介紹 background:
The U-box domain is a modified RING finger motif that has been implicated in the ubiquitin/proteasome system. The ubiquitin-conjugating enzyme 7-interacting protein 5 (UIP5), also designated U-box domain-containing protein 5 or RING finger protein 37, contains 1 RING-type zinc finger and 1 U-box domain. UIP5 has been shown to interact with UBCH7, an enzyme that mediates selective degradation of abnormal proteins. The gene encoding UIP5 maps to chromosome 20, which houses over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.

Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. xy-0266R    MAP65擬南芥MAP65蛋白抗體
xy-11201R    Musashi 1神經干細胞RNA結合蛋白Musashi1抗體
xy-11179R    MAdCAM1粘膜細胞粘附分子1抗體
xy-4943R    MPO髓過氧化物酶抗體
xy-11352R    MAGI1膜相關鳥苷酸反轉激酶1抗體
xy-11353R    Munc13 神經突觸前膜胞內蛋白13抗體
xy-11322R    Membralin高度保守基因相關蛋白Membralin抗體
xy-11320R    MNX1運動神經元及胰腺同源蛋白1抗體
xy-11184R    MOBP少突膠質細胞髓鞘相關蛋白抗體
xy-11189R    MRCK alphaCDC42結合蛋白激酶α抗體（MRCKα）
xy-1047R    MyD88髓樣分化蛋白抗體
xy-0337R    Myelin Protein Zero外周髓磷脂P0蛋白/P0蛋白抗體
xy-0027R    Melatonin Receptor 1A褪黑素受體1A/松果體素受體1A抗體
xy-3550R    Myogenin肌細胞生成素抗體
xy-3296R    Phospho-Myt1(Ser83)磷酸化髓鞘轉錄因子1抗體
xy-3503R    Mre11DNA損傷關鍵蛋白Mre11抗體
xy-3293R    Phospho-Mre11 (Ser676)磷酸化DNA損傷關鍵蛋白Mre11抗體
xy-3504R    MST1蛋白激酶MST抗體
xy-3294R    Phospho-Mst1(Thr183) + Mst2(Thr180)磷酸化蛋白激酶MST抗體
xy-3295R    Phospho-MYL(Ser19)磷酸化肌球蛋白輕鏈2抗體
xy-3505R    Myt1髓鞘轉錄因子1抗體
xy-1352R    MCL1髓樣細胞白血病-1抗體
xy-1369R    MAP2微管相關蛋白2抗體
xy-9470R    MEF2B肌細胞增強因子2B抗體
xy-9471R    MESP1心血管發(fā)育中胚層相關蛋白1抗體
xy-9440R    MTA2轉移相關蛋白2抗體
xy-9375R    MYCBP2MYC結合蛋白2抗體
xy-9314R    MAP7D1精氨酸/脯氨酸富含卷曲蛋白1抗體
xy-9313R    MAP-9微管相關蛋白9抗體
xy-9315R    MKLP1有絲分裂驅動蛋白樣1抗體
xy-1061R    Myeloperoxidase/c-ANCA 髓過氧化物酶抗中性粒細胞胞質IgG抗體
xy-0774R    Mouse IgA兔抗小鼠IgA抗體