ZRANB3蛋白抗體

英文名稱 ZRANB3
中文名稱 ZRANB3蛋白抗體
別    名 4933425L19Rik; MGC105033; MGC75012; OTTHUMP00000197449; Zinc finger Ran-binding domain-containing protein 3; Zinc finger, RAN- binding domain containing 3; ZRAB3_HUMAN; Zranb3.
 
說(shuō) 明 書 0.2ml  
研究領(lǐng)域 轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Cow, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 123kDa
細(xì)胞定位 細(xì)胞核 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZRANB3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed
產(chǎn)品介紹 background:
Zinc finger Ran-binding domain-containing protein 3 (ZRANB3) is a 1079 amino acid gene product that belongs to the SNF2/RAD54 helicase family. Other family members are known to be involved in DNA repair and mitotic recombination. This family of proteins often plays an active role in recombination processes in cooperation with other members of the RAD52 epistasis group. The ZRANB3 product contains one helicase ATP-binding domain, one helicase C-terminal domain and one RanBP2-type zinc finger. RanBP2-type zinc fingers mediate the helicase binding to RNA. Similar to other Ran-binding zinc finger proteins, ZRANB3 likely acts as a splice factor for alternative splicing events of pre-mRNA transcripts. ZRANB proteins may also interfere with constitutive 5'-splice site selection.

Function:
DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

Subunit:
Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via 'Lys-63'-linked polyubiquitin). 

Subcellular Location:
Nucleus. Chromosome. Note=Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA. xy-5002R    PCK2磷酸羧化酶2抗體
xy-5007R    PGLS磷酸葡萄糖酸內(nèi)酯酶抗體
xy-4162R    PP2CA蛋白磷酸酶2C亞型α抗體
xy-4157R    PRKD3蛋白激酶C nu型抗體
xy-5564R    phospho-PRKD3(Ser41)磷酸化蛋白激酶C nu型抗體
xy-5579R    phospho-PIK3C3(Ser282)磷酸化磷脂酰肌醇激酶3催化亞單位3抗體
xy-2970R    PHGDH磷酸甘油酸脫氫酶抗體
xy-5569R    phospho-PRL (Ser163)磷酸化泌乳素抗體
xy-2593R    pro-caspase-3半胱天冬酶-3酶原抗體
xy-12562R    Phospho1細(xì)胞質(zhì)磷酸酶1抗體
xy-12313R    PHEX維生素D低磷性佝僂病蛋白
xy-12324R    PTCHD2多通道膜蛋白PTCHD2抗體
xy-12325R    PTCHD3修補(bǔ)相關(guān)蛋白PTCHD3抗體
xy-4148R    PKMYT1髓鞘轉(zhuǎn)錄因子1激酶抗體
xy-5531R    phospho-PKMYT1(Thr495)磷酸化髓鞘轉(zhuǎn)錄因子1激酶抗體
xy-5532R    Phospho-PDGFRA(Tyr988)磷酸化血小板源性生長(zhǎng)因子受體α
xy-5533R    Phospho-PDGFRA(Tyr572)+PDGFRB(Tyr579) 磷酸化血小板源性生長(zhǎng)因子受體α
xy-5534R    Phospho-PDGFRA(Tyr762)磷酸化血小板源性生長(zhǎng)因子受體α
xy-2282R    PPO兒茶酚氧化酶PPO抗體
xy-2329R    PKC epsilon蛋白激酶C抗體
xy-3789R    Perilipin A脂滴包被蛋白Perilipin-A抗體
xy-3833R    PABP多聚腺苷酸結(jié)合蛋白抗體
xy-9031R    PAS1C1核纖層蛋白A相關(guān)結(jié)構(gòu)蛋白1抗體
xy-9034R    PCID2PCID2蛋白抗體
xy-9029R    PAPSS1腺苷酸硫酸激酶1抗體
xy-9030R    PAPSS2腺苷酸硫酸激酶2抗體