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Nuvia IMAC Resin is a next-generation affinity chromatography media, with ultra-high capacity over a range of pH and flow rates, that provides a wide experimental design space for many applications.

Nuvia IMAC Resin, based on Nuvia Beads, contains nitrilotriacetic acid (NTA) as the chelating ligａnd for di- or trivalent metal ions. The chemical structure of NTA permits highly selective binding of recombinant histidine-tagged proteins when charged with Ni2+ or other transition metals, such as Zn2+ or Cu2+.
Due to superior mass transfer characteristics, Nuvia IMAC Resin offers high capacity at high flow rates. The resin can be used under either nondenaturing or denaturing conditions.

Features and Benefits of Nuvia IMAC Resin
Best-in-class binding capacity at fast flow rates
Rapid mass transfer kinetics
Efficient resolution of biomolecules from crude feedstreams
Stable at pH 2–14, providing excellent NaOH stability

Applications of Nuvia IMAC Resin
For purifying biomolecules in a variety of workflows:
Excellent single-step purity via affinity chromatography
Quick, efficient separation of biomolecules
Contaminant removal
Robust base matrix

This IMAC resin is compatible with 8 M urea, 6 M guanidine HCl, 1 M NaOH, alcohol up to 20% (v/v), and with common detergents, salts, reducing agents, and all commonly used aqueous buffers.

Packaging Options

Bulk Nuvia IMAC Resin
25 ml
100 ml
500 ml


Use these 5 ml cartridges with the NGC™ Chromatography System or any low- to medium-pressure chromatography system.

More Information
Download the for detailed column packing recommendations and protocols for optimal protein isolation and column regeneration, cleaning, sanitizing, and storage.

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