人胎盤膠原蛋白 Collagen from human placenta
C5533 - Bornstein and Traub Type IV, powder, BioReagent, suitable for cell cultureDOWNLOAD MSDS (PDF)
別名: Collagen Type 4

CAS號(hào): 9007-34-5

人胎盤膠原蛋白 性質(zhì)
相關(guān)類型 2D Cell Culture, Adhesion, Attachment, and Matrix Factors, Adhesion, Attachment, and Matrix Factors for Stem Cell Expansion, Attachment Factors, Attachments Factors,
Cell Culture, Cell Culture Supplies, Collagen, Core Bioreagents, General Stem Cell Biology, Life Science Reagents for Cell Culture, Proteins and Derivatives, Reagents and Supplements, Scale-Up Cell Culture using Corning Roller Bottles, Stem Cell Differentiation, Stem Cell Expansion, Structural Proteins
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product line BioReagent
form powder
surface coverage 6?10 μg/cm2
total impurities HIV and hepatitis B, none detected (PCR)
  HIV and hepatitis B, none detected
solubility acetic acid: soluble0.5-2.0 mg/mL (Dissolve for several hours at 2-8 °C, occasionally swirling.)
suitability suitable for cell culture
storage temp. −20°C
Gene Information Research your gene in Your Favorite Gene powered by Ingenuity
human ... COL4A1(1282), COL4A2(1284), COL4A3(1285), COL4A4(1286), COL4A5(1287), COL4A6(1288)

Show all 10 properties
描述
Application
Epithelial cells, endothelial cells, muscle cells, nerve cells

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General description
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Type IV collagen is highly expressed in chorionic villi cytotrophoblast cells. The same cells are also capable of expressing the cleaving enzyme, 70S type IV collagenase.1

Preparation Note
Prepared by a modification of the pepsin extraction method of Niyibizi, C. et. al

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Biochem/physiol Actions
Type IV collagen is a sheet-forming type of collagen found in basement membranes where it serves a critical scaffolding function. In mammals, six proteins make up the type IV collagen family with the distribution of family members being tissue-specific. Structurally, three collagen IV alpha chains assemble to form a flexible heterotrimeric protomer that can self-assemble into network polymers.

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Tissue injury in the autoimmune disease Goodpasture syndrome is due to pathogenic autoantibodies targeting the Collagen IV α3 chain . Mutations in COL4A5 are associated with Alport syndrome.