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抑制劑，調(diào)節(jié)劑，API，天然產(chǎn)物，各種類型化合物庫
| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL；50 mg；100 mg |
|---|---|---|---|
| 貨號 | HY-13704 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
SN-38
產(chǎn)品活性：SN-38 (NK012) 是拓?fù)洚悩?gòu)酶I抑制劑伊立替康的活性代謝產(chǎn)物。 SN-38 (NK012) 抑制DNA合成和RNA 合成的IC50分別為0.077 和 1.3 μM。
研究領(lǐng)域：Cell Cycle/DNA Damage | Autophagy
作用靶點(diǎn)：Topoisomerase | Autophagy
In Vitro: The IC50 values for LoVo, HCT116, and HT29 cell lines is 20 nM, 50 nM, 130 nM, respectively. In all three SN-38 (NK012) resistant cell lines * activity is maintained in the presence of high concentrations of SN-38.
In Vivo: SN-38 (NK012), the active and toxic metabolite of the anticancer prodrug Irinotecan. At 30 minutes after administration, Irinotecan plasma concentrations in Slco1a/1b(?/?) mice are 1.9-fold higher than in the wild-type mice (1.89 vs. 1.01 μM, respectively), whereas SN-38 (NK012) plasma concentrations of Slco1a/1b(?/?) mice are 8-fold higher compare with wild-type mice (0.4 μg/mL vs. 0.05 μg/mL, respectively). Overall plasma exposure [AUC(5-240)] of Irinotecan is 1.7-fold higher in Oatp1a/1b knockout mice versus wild-type mice (209.8±6.7 vs. 120.9±4.4 μM/min; P<0.01), and 2.9-fold higher for SN-38 (50±2.9 vs. 12±2 μM/min; P<0.001).
相關(guān)產(chǎn)品：Drug Repurposing Compound Library | Clinical Compound Library | Clinical Compound Library Plus | Anti-Cancer Compound Library | Cell Cycle/DNA Damage Compound Library | Drug Repurposing Compound Library Plus | Bioactive Compound Library Plus | Autophagy Compound Library | Doxorubicin hydrochloride | Etoposide | Irinotecan | Campathecin | Aldoxorubicin | Epirubicin hydrochloride | Daunorubicin Hydrochloride | Topotecan Hydrochloride | Berberine chloride hydrate | Mitoxantrone | Idarubicin hydrochloride | β-Lapachone | Daun02 | Exatecan Mesylate | Betulinic acid | Teniposide | Amsacrine | Ellipticine hydrochloride | Pirarubicin | Banoxantrone dihydrochloride | Amonafide | Genz-644282 | TAS-103 dihydrochloride | Voreloxin Hydrochloride | Bisantrene
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