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CLI-095 Resatorvid瑞沙托維 TAK-242
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| 供貨周期 | 現(xiàn)貨 | 規(guī)格 | 10 mM * 1 mL;5mg;10mg;50mg;100mg;200mg |
|---|---|---|---|
| 貨號 | HY-11109 | 應(yīng)用領(lǐng)域 | 生物產(chǎn)業(yè) |
Resatorvid瑞沙托維 TAK-242
MCE 站：Resatorvid
產(chǎn)品活性：Resatorvid (TAK-242) 是一種有效的 TLR4 信號傳導(dǎo)抑制劑，可選擇性地抑制TLR-介導(dǎo)的細胞因子和一氧化氮的產(chǎn)生。
研究領(lǐng)域：Immunology/Inflammation | Autophagy
作用靶點：Toll-like Receptor (TLR) | Autophagy
Resatorvid瑞沙托維 TAK-242
In Vitro: In RAW264.7 cells and mouse peritoneal macrophages, Resatorvid (TAK-242) suppresses lipopolysaccharide (LPS)-induced production of NO, tumor necrosis factor-α (TNF-α), and interleukin (IL)-6, with IC50 of 1.1 to 11 nM. Resatorvid (TAK-242) also suppresses the production of these cytokines from LPS-stimulated human peripheral blood mononuclear cells (PBMCs) at IC50 values from 11 to 33 nM.
In Vivo: Resatorvid (TAK-242) apparently reduces the serum anti-dsDNA levels in both genotype mice. Alternatively, IFN-γ, TNF-α, and IL-1β production is markedly inhibited by Resatorvid (TAK-242), but their concentrations are still greatly higher than those in NS-treated counterparts. Resatorvid (TAK-242) pre-stress administration prevents the accumulation of potentially deleterious inflammatory and oxidative/nitrosative mediators in the brain frontal cortex of rats. Resatorvid (TAK-242) i.v. administration at the beginning of the stress session completely blocks TLR-4 mRNA and protein upregulation after stress exposure.
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