上海科敏生物銷售DLAT (4A4-B6-C10) Mouse mAb #12362 Cell Signaling，CST原裝品質(zhì)，*，訂購DLAT (4A4-B6-C10) Mouse mAb #12362 Cell Signaling，詳情請咨詢銷售人員！
產(chǎn)品詳細(xì)參數(shù)如下>>>>

產(chǎn)品名稱：DLAT (4A4-B6-C10) Mouse mAb #12362 Cell Signaling
貨號：12362
品牌：CST(cell signaling)
抗體來源：Mouse
克隆類型：Monoclonal
規(guī)格：

抗體應(yīng)用：

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on * sequence homology.
特異性/敏感度：DLAT (4A4-B6-C10) Mouse mAb recognizes endogenous levels of total DLAT protein.
來源及純化方法：Monoclonal antibody is produced by immunizing animals with a recombinant human DLAT protein.
抗體背景：

Dihydrolipoamide acetyltransferase (DLAT) transfers an acetyl group from pyruvate to CoA to synthesize acetyl-CoA (1-4). This protein, also known as the E2 subunit of the pyruvate dehydrogenase complex (PDC-E2), has been implicated in the literature as the primary autoantigen in primary biliary cirrhosis (2-5). Antimitochondrial antibodies (AMAs) are likely formed when DLAT is exposed to the immune system in apoptotic cells of the bile duct (3,5). Research studies have shown that in some cases, cosmetics, NSAIDs, chewing gum, acetaminophen, and other compounds could trigger exposure of DLAT in sensitive individuals (3). The presence of AMAs is often detectable before disease diagnosis (4,5). Research studies have also shown that activation of the Toll-like receptor-3 (TLR-3) pathway is involved in the progression from a subclinical to clinical state (4).

關(guān)鍵詞：CST，抗體，一抗{byao_back}{byao_back2}

相關(guān)產(chǎn)品：
Anti-MAGE-1黑色素瘤相關(guān)抗原抗體
Anti-SOCS3細(xì)胞因子信號傳導(dǎo)抑制蛋白3抗體
ab102600/Anti-ADHFE1 antibody
ab101976/Anti-C9orf152 antibody
Anti-Thy-1/CD90/ Thy1.1CD90抗體
Anti-Integrin alpha 5/CD49e/ITGA5整合素α5抗體Integrin α5
ab103726/Anti-FAM151A antibody
Anti-CA15-3/Muc1粘蛋白-1/上皮膜抗原抗體
ab103943/Anti-DHRS2 antibody
ab103696/Anti-GCNT2 antibody
Anti-TRA16睪丸激素孤兒受體相關(guān)蛋白抗體
Anti-CDK6周期素依賴性激酶6抗體
ab100872/Anti-ABP1 antibody
ab101405/Anti-ATAD3A antibody
Anti-c-fosc-fos抗體
Anti-WDR26心肌缺血預(yù)處理正調(diào)節(jié)蛋白2抗體