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Bioinspired DNA nanocockleburs for targeted delivery of doxorubicin
Si Suna,1 , Nihad Cheragab,1 , Han-Ning Jiangb,1 , Qian-Ru Xiaob , Peng-Cheng Gaoa , Yang Wanga,
Ying-Ying Weia , Xiao-Wei Wangc , Yong Jianga,*
a School of Chemistry and Chemical Engineering, Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China
b State Key Laboratory of Bioelectronics, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, PR China
c Department of Cardiovascular Surgery, The First Affiffiffiliated Hospital of Nanjing Medical University, Nanjing 210036, PR China
ARTICLE INFO
Keywords:
Self-assembly
DNA nanocockleburs
Target drug delivery
Aptamers
ABSTRACT
A variety of three-dimensional DNA assemblies have been proposed as drug carriers owing to their good bio
compatibility and easy fabrication. In this study, inspired by the structure of cockleburs, a novel aptamer
tethered DNA assembly was developed for effffective targeted drug delivery. The Apt-nanocockleburs were fab
ricated via a facile process of DNA base pairing: four complementary DNA single strands, including one aptamer
ended strand and three sticky-end strands, were applied to pair with each other. The main body of the nano
cockleburs can load doxorubicin (Dox) whilst the covered aptamer spines bind to the target MCF-7 cells. The self
assembled Apt-nanocockleburs exhibit higher cell uptake as well as increased cytotoxicity to MCF-7 cells than
DNA nanocockleburs without aptamers. This study provided a DNA constructing platform to produce new drug
carriers with high selectivity for cancer targeted drug delivery.