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BPS Bioscience Inc.
中級會員 | 第3年

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AP1 Luciferase Reporter Lentivirus (JNK Signaling Pathway)

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品       牌BPS Bioscience

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更新時間:2023-10-11 09:25:01瀏覽次數(shù):180次

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保存條件:-80°C(dryice)保質(zhì)期:3-18month英文名:AP1LuciferaseReporterLentivirus(JNKSignalingPathway)數(shù)量:1供應(yīng)商:BPSBioscienceInc
  • 保存條件:

    -80°C (dry ice)

  • 保質(zhì)期:

    3-18 month

  • 英文名:

    AP1 Luciferase Reporter Lentivirus (JNK Signaling Pathway)

  • 數(shù)量:

    1

  • 供應(yīng)商:

    BPS Bioscience Inc.

  • CAS號:

    /

  • 規(guī)格:

    500 µl x 2

The stress-activated protein kinase/c-jun N-terminal kinase (SAPK/JNK) family of proteins includes mitogen-activated protein kinases (MAPKs) that are activated by stress, inflammatory cytokines, mitogens, oncogenes, and inducers of cell differentiation and morphogenesis. Upon activation of the SAPK/JNK pathway, MAP Kinase Kinases phosphorylate and activate JNKs. The activated JNKs translocate to the nucleus where they phosphorylate and activate transcription factors such as c-Jun. c-Jun then binds to the activator protein-1 (AP1) response element and induces AP1 transcription.
The AP1 Luciferase Reporter Lentivirus are replication incompetent, HIV-based, VSV-G pseudotyped lentiviral particles that are ready to be transduced into almost all types of mammalian cells, including primary and non-dividing cells. The particles contain a firefly luciferase gene driven by AP1 response element located upstream of the minimal TATA promoter. After transduction, activation of the JNK signaling pathway and AP1 mediated activity in the target cells can be monitored by measuring the luciferase activity.
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