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FB23-2

CAS No. : 2243736-45-8

產(chǎn)品活性：FB23-2 is a potent and selective inhibitor of mRNA N⁶-methyladenosine (m⁶A) demethylase FTO, with an IC₅₀ of 2.6 μM. FB23-2 has anti-proliferation activity. FB23-2 can be used for the research of acute myeloid leukemia (AML).

研究領(lǐng)域：Apoptosis

作用靶點：Apoptosis

In Vitro: FB23-2 dramatically suppresses proliferation and promotes the differentiation/apoptosis of human AML cell line cells and primary blast AML cells.
FB23 inhibits the proliferation of NB4 and MONOMAC6 cells, with IC₅₀ values of 0.8 μM and 1.5 μM.
FB23-2 (20 μM; 72 hours) displays anti-proliferation effect via upregulating global m⁶A levels.
FB23-2 (0.5-5 μM; 24-72 hours) significantly suppresses the proliferation of BM cells from these two models in a dose-dependent manner.
FB23-2 exhibits FTO-dependent anti-proliferation activity and promotes myeloid differentiation and apoptosis.
FB23-2 (1-20 μM; 72 hours) significantly increases the mRNA and protein levels of ASB2 and RARA in NB4 and MONOMAC6 cells.
FB23-2 induces apoptosis (1-20 μM; 48-72 hours) and cell cycle arrest (5-20 μM; 24 hours) at G1 stage in AML cells.

In Vivo: FB23-2 (2 mg/kg; i.p.; daily; for 10 days) substantially suppresses leukemia progression and prolongs survival.
FB23-2 exhibits elimination half-life (rat 6.7 h) and C_max (rat 2421.3 ng/mL) following intraperitoneal injection (rat 3 mg/kg).

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