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BPS Bioscience Inc.
中級會員 | 第3年

13829799985

當前位置:BPS Bioscience Inc.>>Cell Signaling Pathway Cell Lines>> 78811TL1A-Responsive Luciferase Reporter Jurkat Cell Line

TL1A-Responsive Luciferase Reporter Jurkat Cell Line

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產(chǎn)品型號78811

品       牌BPS Bioscience

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更新時間:2024-11-26 13:23:26瀏覽次數(shù):153次

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Description

TNF-like ligand 1A (TL1A)-Responsive Luciferase Reporter Jurkat Cell Line is a TL1A-responsive DR3/NF-kB luciferase reporter Jurkat cell line expressing firefly luciferase under the control of an NF-kB response element, and with stable expression of human DR3 (death receptor 3; TNFRSF25; NM_003790.3). Expression of the firefly luciferase gene is driven by NF-kB response elements located upstream of the minimal TATA promoter. Activation of the NF-kB signaling pathway by the DR3 ligand TL1A (TNF-like Protein 1A; TNFSF15) can be monitored by measuring luciferase activity.

This cell line has been validated to be responsive to TL1A and TNF-α stimulation. TL1A stimulation was blocked by the neutralizing anti-TL1A antibody (BPS Bioscience #101729).

Figure 1: Schematic representation of the TL1A response in TL1A Responsive Luciferase Reporter Jurkat Cell Line.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

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