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Source

Rabbit

Applications

IHC,WB

Reactivity

Human, Mouse, Rat

Dilution

IHC 1:50-200, WB 1:500-2000

Storage

-20°C/1 year

Specificity

This antibody detects endogenous levels of human CD105

Source/Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen

Synthesized peptide derived from human CD105

Uniprot No

P17813

Alternative names

Endoglin (CD antigen CD105)

Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Background

endoglin(ENG) Homo sapiens This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013],

Other

ENG END, CD105

Concentration

1 mg/ml