CHRNA7 抗體

抗原
Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7)
別名 CHRNA7-2, NACHRA7, BTX, NARAD, nAChRa7, Acra7, alpha7
抗原表位
其他選擇 N-Term, AA 8-37
N-Term(15),AA 7-37 (7),AA 493-502 (3),Internal Region (3),C-Term (2),Extracellular Domain (2),Middle Region (2),AA 424-473 (1),AA 8-37 (1),Exon 5 (1),Variant alpha (1)
適用
其他選擇 Human
Human(45),Murine (19),Rat ((Rattus)) (19),Chicken (15),Bovine (4),Dog (Canine) (3),Pig (Porcine) (1)
宿主
其他選擇 Rabbit
Rabbit(39),Goat (4),Mouse (2)
克隆類(lèi)型 (克隆位點(diǎn))
多克隆 (RB34036)
標(biāo)記
其他選擇 非結(jié)合性
Biotin(2),FITC (2),HRP (2),APC (1),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Alkaline Phosphatase (AP) (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1),PE (1)
應(yīng)用范圍
其他選擇 Western Blotting (WB)
Western Blotting (WB)(31),ELISA (10),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7),Enzyme Immunoassay (EIA) (3),Immunocytochemistry (ICC) (2),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (2),Immunohistochemistry (Frozen Sections) (IHC (fro)) (2),Immunohistochemistry (IHC) (2),Immunoprecipitation (IP) (2),Immunofluorescence (IF) (1)
[Pubmed] 2 references available
規(guī)格 400 μL
發(fā)貨至 中國(guó) (更改)
發(fā)貨時(shí)間 9至13個(gè)工作日

CHRNA7 抗體

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產(chǎn)品細(xì)節(jié)

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免疫原 This CHRNA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 AA from the N-terminal region of human CHRNA7.
克隆位點(diǎn) RB34036
亞型 Ig
特異性 This CHRNA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-37 amino acids from the N-terminal region of human CHRNA7.
純化方法 This antibody is purified through a protein A column, followed by peptide affinity purification.

目標(biāo)詳細(xì)情況

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別名 CHRNA7
背景 The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms: Neuronal acetylcholine receptor subunit alpha-7,CHRNA7,NACHRA7
分子量 56449 DA
基因ID 1139
NCBI Accession NP_000737
UniProt P36544
研究領(lǐng)域 Cell Signaling, Cell Structure, Protein Modifications, Neurology

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應(yīng)用備注 WB = 1:1000
限制 For Research Use only

貯存及處理

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貯存及處理

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狀態(tài) Liquid
濃度 0.5 mg/mL
緩沖液 PBS with 0.09 % (W/V) sodium azide
儲(chǔ)存液 Sodium azide
注意事項(xiàng) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
儲(chǔ)存條件 4 °C/-20 °C
儲(chǔ)存方法 CHRNA7 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
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