STRA6抗體

抗原
Stimulated By Retinoic Acid 6 (STRA6)
別名 RGD1307551, MCOPCB8, MCOPS9, AI891933
抗原表位
其他選擇 AA 565-575, Cytoplasmic Domain
C-Term(17),AA 593-622 (8),AA 482-509 (7),N-Term (3),AA 1-667 (2),AA 187-199 (2),AA 586-614 (2),AA 255-275 (1),Cytoplasmic Domain (1),Internal Region (1)
適用
其他選擇 Human
Human(37),Murine (22),Rat ((Rattus)) (17),Dog (Canine) (13)
宿主
其他選擇 Rabbit
Rabbit(38),Goat (5),Mouse (1)
克隆類型
多克隆
標(biāo)記
其他選擇 非結(jié)合性
Biotin(3),FITC (3),HRP (3),PE (3),APC (2),Alkaline Phosphatase (AP) (2),Alexa Fluor 350 (1),Alexa Fluor 488 (1),Alexa Fluor 555 (1),Alexa Fluor 647 (1),Cy3 (1),Cy5 (1),Cy5.5 (1),Cy7 (1)
應(yīng)用范圍
其他選擇 Western Blotting (WB)
Western Blotting (WB)(32),ELISA (16),Flow Cytometry (FACS) (11),Immunofluorescence (Paraffin-embedded Sections) (IF (p)) (10),Immunohistochemistry (IHC) (8),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5),Immunoassay (IA) (2),Enzyme Immunoassay (EIA) (1),Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)) (1)
[Pubmed] 2 references available
規(guī)格 0.1 mg
發(fā)貨至 中國 (更改)
發(fā)貨時間 29至35個工作日

STRA6抗體

產(chǎn)品細節(jié)

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產(chǎn)品細節(jié)

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免疫原 Synthetic amidated peptide from Human Retinoic Acid Responsive protein Stra6. The epitope location is in the third large intra cytoplasmic loop (Human: aa 565-575).
亞型 IgG
特異性 This antibody detects a band of ~99?kDa.
交叉反應(yīng) （詳細） Species reactivity (tested):Human.
純化方法 Affinity Chromatography on immobilized antigen

目標(biāo)詳細情況

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目標(biāo)詳細情況

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別名 STRA6
背景 Stra6 gene encodes a membrane bound retinoic acid sensitive protein that facilitates the transport of vitamin A thru its soluble retinol binding protein complex. The transcription of Stra6 is directly regulated by the cellular levels of retinoic acid, which is a strong teratogen when exposed at elevated concentrations during early embryogenesis. The Stra 6 gene was studies in two human fetuses from consanguineous families with Matthew-Wood syndrome. These subjects exhibited severe microphthalmia, pulmonary agenesis, bilateral diaphragmatic eventration, duodenal stenosis, pancreatic malformations, and intrauterine growth retardation (1). In view of the increasing evidence that retinoic acid (RA) is a crucial signaling molecule during vertebrate development, several studies were initiated to systematically isolate the genes whose expression is induced by retinoic acid treatment at various exposure times. Several genes are induced in Pluripotent mouse P19 embryonal carcinoma cells (P19EC) RA treatment. At least 50 different cDNA fragments corresponding to RA-induced genes were isolated, 6 of them are known proteins, 4 of which are described as RA inducible, while the remaining 40 are unknown and novel genes. Two of these unknown novel genes are Stra1 and Stra6. Stra1 corresponds to the mouse ligand for Cek5 receptor protein tyrosine kinase and Stra6 is a vitamin A transporter (1). Stra6 is a membrane bound protein containing 10 TMD characteristic of solute carrier proteins. Stra6 protein is expressed in various tissues including fibroblasts and eye, a detailed analysis of distinct parts of an adult eye revealed expression in sclera, retina, retinal pigment epithelium and trabecular mashwork but not in choroid and iris (2). A number of mutations in the Stra6 (chromosome 15) gene have been studied. A homozygous deletion generating a premature stop codon that led to absence of the immunoreactive protein in patient fibroblasts culture and three miss-sense mutations (P90L, P293L and T321P) caused significant alteration in the geometry of the loops connecting the transmembrane helices of Stra6. Two other mutations in the C-terminal region caused aberration in the SH2 binding motifs and in the phosphorylation of the Stra67 protein (2). Patients with these mutations show anophthalmia and distinct eyebrows as common signs along with alveolar dysplasia or a common congenital heart defect and diaphragmatic hernia. Stra6 is a 99 kDa membrane bound protein with 10 TMD as commonly seen in all membrane transporter proteins.Synonyms: FLJ12541, PP14296, Stimulated by retinoic acid gene 6 protein homolog
基因ID 64220
NCBI Accession NP_001136089
UniProt Q9BX79

使用細節(jié)

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使用細節(jié)

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應(yīng)用備注 This antibody is ideal for Western Blot (> 1/500).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
限制 For Research Use only

貯存及處理

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貯存及處理

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濃度 0.69-1.00 mg/mL
緩沖液 Stabilization buffer
注意事項 Avoid repeated freezing and thawing.
儲存條件 -20 °C
儲存方法 Store the antibody undiluted (in aliquots) at-20 °C.

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