英文名稱 BNP
中文名稱 腦鈉素抗體
別    名 BNP 32; Brain natriuretic peptide 32; Gamma brain natriuretic peptide; Natriuretic peptide brain type; Natriuretic peptide precursor B; Natriuretic peptides B; NPPB; NPPB protein; ANFB_HUMAN; ANFB_MOUSE.
 腦鈉素抗體
 
說 明 書 0.1ml  0.2ml  
研究領域 心血管  信號轉(zhuǎn)導  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat, 
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC= IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 13kDa
細胞定位 分泌型蛋白 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse BNP (100-121aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
  
產(chǎn)品介紹 background:
Brain natriuretic peptide (BNP) circulates in blood as a peptide hormone with natriuretic, vasodilatory and renin inhibitory properties. BNP is secreted predominantly by the left ventricular myocytes in response to volume expansion and pressure overload. BNP belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. These peptides are characterized by a common 17 amino acid ring structure with a disulfide bond between two cystein residues. This ring structure shows high homology between different natriuretic peptides (eleven of the 17 amino acid residues are homologous in the ring of each of the natriuretic peptides). BNP is a 32 amino acid peptide with disulfide bond between the cysteine residues Cys10 and Cys26. In earlier studies it has been demonstrated that BNP concentration in blood increases with the severity of congestive heart failure. Quantitative measurement of BNP in blood provides an objective indicator of congestive heart failure severity

Function:
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Subcellular Location:
Secreted.

Tissue Specificity:
Brain and also in atria, but at much lower levels than ANP.

Similarity:
Belongs to the natriuretic peptide family.

Gene ID:
18158

Database links:

Entrez Gene: 4879 Human

Entrez Gene: 25105 Rat

Omim: 600295 Human

SwissProt: P16860 Human

SwissProt: P13205 Rat

Unigene: 219140 Human

Unigene: 3835 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
xy-12916R phospho-c-Kit(Tyr568 + Tyr570)磷酸化原癌基因c-kit抗體
xy-12918R phospho-C-REL (Ser503)磷酸化淋巴細胞衍生C-型凝集素抗體
xy-15149R C2orf392號染色體開放閱讀框39抗體
xy-15150R C2orf492號染色體開放閱讀框49抗體
xy-15151R C2orf502號染色體開放閱讀框50抗體
xy-13095R ERCC8科凱恩氏綜合癥相關蛋白/早衰蛋白CSA抗體
xy-12919R phospho-Cytokeratin 8 (Ser73)磷酸化細胞角蛋白8抗體
xy-12920R phospho-Cytokeratin 8 (Ser431)磷酸化細胞角蛋白8抗體
xy-12921R phospho-CK18(Ser52)磷酸化細胞角蛋白18抗體
xy-12922R Cytohesin 2胞粘蛋白2抗體
xy-12923R Cytochrome P450 2A6細胞色素CPA6抗體
xy-12924R CYP3A1細胞色素CYP3A抗體
xy-12927R CYP20A1細胞色素cP450 CYP20A1抗體
xy-12926R CYP1B1細胞色素cP4501B1抗體
xy-12928R CYP26A1細胞色素cP450 CYP26A1抗體
xy-12929R phospho-Cyclin E(Thr77)磷酸化周期素E抗體
xy-12930R phospho-Cyclin E2 (Thr392)磷酸化周期素E2抗體
xy-12045R Cyclin M3周期素M3抗體
xy-12060R Cyclin Y周期素Y/X抗體
xy-12155R phospho-Cyclin D3 (Thr283)磷酸化周期素D3抗體
xy-12162R CYB5R3細胞色素b5還原酶3抗體
xy-11464R CWC22CWC22蛋白抗體
xy-15349R C9orf959號染色體開放閱讀框95抗體
xy-13794R C19orf6719號染色體開放閱讀框67抗體
xy-12426R phospho-Casein kinase I isoforms gamma 1+2+3 ( Tyr263)磷酸化酪蛋白激酶1γ1+γ2+γ3抗體
xy-8860R Coproporphyrinogen III Oxidase原卟啉氧化酶3抗體
xy-8987R Connexin 43間隙連接蛋白43抗體