英文名稱 Arginase II
中文名稱 精氨酸酶2抗體
別    名 ARG 2; ARG2; ARGI2_HUMAN; Arginase2; Arginase liver; Arginase type II; Arginase II; ArginaseII; Arginase-II; Arginase1.
 精氨酸酶2抗體
 說(shuō) 明 書 0.1ml  
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 36kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human Arginase II
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
產(chǎn)品介紹 background:
Arginase I (also designated liver-type arginase), which is expressed almost exclusively in the liver, catalyzes the conversion of arginine to ornithine and urea (1). The human arginase I gene, which maps to chromosome 6q23, encodes a 322 amino acid protein. Arginase I exists as a homotrimeric protein and contains a binuclear manganese cluster (2-4). Arginase II catalyzes the same reaction as arginase I, but differs in its tissue specificity and subcellular location (5,6). Specifically, arginase II localizes to the mitochondria (5,6). Arginase II is expressed in non-hepatic tissues, with the highest levels of expression in the kidneys, but, unlike arginase I, is not expressed in liver (5,6). The human arginase II gene, which maps to chromosome 14q24.1, encodes a 354 amino acid protein (3,5-7). In addition, arginase II contains a putative amino-terminal mitochondrial localization sequence (5,6).

Function:
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

Subunit:
Homotrimer.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas.

Similarity:
Belongs to the arginase family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
xy-15479R HHLA3HHLA3蛋白抗體
xy-15477R HHIPL2HHIP樣蛋白2抗體
xy-10331R H3N2 Matrix Protein 2A型流感病毒H3N2-M2蛋白抗體
xy-13643R HSH2DHSH2D抗體
xy-4561R Hirudin水蛭素抗體
xy-10086R HLA Class 1 ABC白細(xì)胞抗原A抗體
xy-10202R HPV16 E7人乳頭瘤病毒16型E7抗體
xy-10201R HPV58 E6人類乳頭狀瘤病毒58 E6蛋白抗體
xym-0990M HPV16 E6 protein人類乳頭狀瘤病毒16抗體
xy-10204R HPV18 E7人類乳頭狀瘤病毒18 E7抗體
xy-10203R HPV31 E7人類乳頭狀瘤病毒31 E7抗體
xy-12383R HES2轉(zhuǎn)錄因子HES2抗體
xy-12384R HES3轉(zhuǎn)錄因子HES3抗體
xy-12385R IPMK多磷酸肌醇激酶IPMK抗體
xy-13644R IKAPIKK復(fù)合物相關(guān)蛋白抗體
xy-13645R IQSEC2IQSEC2抗體
xy-13646R Intersectin 2交叉蛋白2抗體
xy-13590R Inosine triphosphate pyrophosphatase三磷酸肌苷焦磷酸酶抗體
xy-15493R IDO吲哚胺2,3-雙加氧酶抗體
xy-10087R IL-19白細(xì)胞介素19抗體
xy-7130R Inhibin Alpha抑制素A/Inhibin α抗體
xy-7337R Islet-1+2胰島素基因增強(qiáng)結(jié)合蛋白1/2抗體