瑞士regenHU廠家的EMC-Bioink™系列生物墨水現(xiàn)成的有五種，但可以針對特定應(yīng)用進(jìn)行定制。
系列被描述為“非牛頓流體材料，有剪切稀化性質(zhì)，能根據(jù)需要和要求提供促進(jìn)細(xì)胞擴(kuò)增、細(xì)胞生長和遷移的三維肽納米纖維支架。"

瑞士regenHU廠家的EMC-Bioink™系列生物墨水現(xiàn)成的有五種，但可以針對特定應(yīng)用進(jìn)行定制。
系列被描述為“非牛頓流體材料，有剪切稀化性質(zhì)，能根據(jù)需要和要求提供促進(jìn)細(xì)胞擴(kuò)增、細(xì)胞生長和遷移的三維肽納米纖維支架。”

 

將使研究人員更容易地增材制造出復(fù)雜的、與真實(shí)有機(jī)組織的結(jié)構(gòu)和功能極其相似的結(jié)構(gòu)。通過提供對機(jī)械強(qiáng)度和細(xì)胞支架的相互作用的控制，EMC-Bioink系列材料可以充當(dāng)獨(dú)立的基質(zhì)，如果需要，也可以整合到一個(gè)結(jié)構(gòu)系統(tǒng)中。

EMC-Bioink有著廣泛的應(yīng)用，可用于各種目的，如研究組織或疾病、藥物發(fā)現(xiàn)、毒性、功效、創(chuàng)造再生植入物等

BIOMATERIALS

Our 3DDiscovery™ and BioFactory™ bioprinters offer a broad portfolio of biomaterials for both soft and hard tissue engineering and drug discovery.
This portfolio is comprised of natural and synthetic hydrogels acting as extracellular-matrix environments to support cell growth (ECM-BioInk™), biomaterials for scaffolding to mimic hard tissues (OsteoInk™) and support materials (STARK™).

OUR BIOMATERIALS AT A GLANCE:

 

Biomaterials

Application

Characteristics

 

HYDROGELS	ECM-a BioInk™	3D Cell culture, migration and proliferation assay	Biosynthetic extracellular matrix with Low net charge
	ECM-b BioInk™		Biosynthetic extracellular matrix with Mid net charge
	ECM-c BioInk™		Biosynthetic charge extracellular matrix with High net charge
	ECM-f BioInk™		Biosynthetic extracellular matrix with Low net charge Functionalized
	ECM-p BioInk™		Biosynthetic extracellular matrix with Low net charge Functionalized

 

SCAFFOLDING

OsteoInk™

Calcium Phosphate biomaterial for hard tissue engineering

Calcium phospahte formulation

 

SUPPORT

STARK™

Support material for Freeform Fabrication

Silicon-based polymer

 

Biosynthetic Hydrogels

ECM-BioInk™, is a peptide nanofiber 3-dimensional scaffold that promotes cell growth and migration.
It utilizes specific peptides that self-assemble from ECM-BioInk™ fluid precursors into highly intertwined hydrated peptide hydrogel fibres when presented with ionic strengths. By inducing a rapid transformation from solution to gel, a peptide nanofiber scaffold is generated.

The ECM-BioInk™ portfolio contains 5 formulations that differ from each other in the electrical net charge which impacts the matrix stiffness and consequently cell proliferation capacity.

ECM- BioInk’s unique properties

• Synthetic (highly reproducible with no batch to batch variation)
• Adaptable matrix stiffness
• Biological building blocks
• Animal free
• Mass transport of nutrients
• Oxygen diffusion
• Bulk distribution of proteins and grow factors
• Optically transparent
• Neutral pH
• Ready to use with cells
• Electrical net charge modulation

BioInk Datasheet

ECM-alpha BioInk™

 

ECM-beta BioInk™

 

ECM-p BioInk™

 

By adjusting the concentration of the ECM-BioInk™ solution, users can control the flexibility of the 3D architecture to meet their application′s specific needs. ECM-BioInk™ is a unique human relevant, synthetic extracellular matrix in which scaffold interaction with cells and small molecules are driven by hydrogen and hydrophobic interactions.

 

SELECT YOUR ECM-BIOINK™ FORMULATION:

BioInk Datasheet

Cell type	ECM- a BioInk™	ECM- b BioInk™	ECM-c BioInk™	ECM-f BioInk™	ECM-f BioInk™	Experiment
FIBROBLASTS	•	•	•	•	•	Proliferation, Migration
Human Embryonic Stem Cells	•	•	•	•	•	Proliferation,  Differentiation
Human Induced Pluripotent Stem Cells	•	•	•	•	•	Proliferation,  Differentiation
Human Mesenchemical Stem Cells	•	•	•	•	•	Proliferation,  Differentiation
Bone Marrow Derived Mesenchemial Stem Cells	•	•	•	•		Proliferation,  Differentiation
Adipose Tissue Derived Mesenchemical Stem Cells	•	•	•	•		Proliferation,  Differentiation
Human Haemopoetic Stem Cells	•	•	•	•		Proliferation,  Differentiation
Human Neuronal Stem Cells	•	•	•			Proliferation,  Differentiation
Cardiac Progenitor Cells	•	•	•	•	•	Proliferation,  Differentiation
Human Endothelial Cells	•	•	•			Proliferation, Migration
Primary Neurons	•	•	•	•		Proliferation, Migration
Cardiomyocytes	•	•	•			Proliferation, Migration
Nucleus Pulposus Cells	•	•	•			Proliferation, Migration
Hepatocytes	•	•	•		•	Proliferation, Migration
Chrondrocytes	•	•	•			Proliferation, Migration
Myocytes	•	•	•	•		Proliferation, Migration
	Order	Order	Order	Order	Order

OSTEOINK™

CALCIUM PHOSPHATE MATERIAL FOR 3D TISSUE PRINTING

OsteoInk™ is a ready-to-use calcium phosphate paste for scaffolding and structural engineering. OsteoInk™ is a highly osteoconductive biomaterial close to the chemical composition of human bone. Dedicated to hard tissue engineering such as bone, cartilage or structural scaffold manufacturing, OsteoInk™ can be combined during the printing process with our biomaterial product portfolio (e.g ECM-BioInk™) to create complex 3D tissue models.
The uniqueness of BioFactory™ and 3DDiscovery™ printers enables freeform fabrication of tissue models with controlled layers, pore structure and biological composition. It enables scientists to mimic nature by combining OsteoInk™ with hydrogels (natural or synthetic), bioactives, scaffolding or support materials.

FACTS

• Designed for BioFactory™ and 3DDiscovery™ tissue printers
• Osteoconductive calcium phosphate material
• For Research and Development
• Available in 5cc cartridge
• Can be combined with BioInk™, STARK or any other type of bioactives and/or biomaterials

BIOINK™

Biosynthetic extracellular matrix

BioInk™ is a chemically-defined hydrogel to support growth of different cell types. It allows cell adhesion, mimics the natural extracellular matrix and is biodegradable. BioInk™ is provided as a ready-to-use chemically-defined hydrogel to print 3D tissue models. Exclusively designed for regenHU’s BioFactory™ and 3DDiscovery™ tissue and bio-printers.

A versatile, chemically-defined hydrogel, supporting cell attachment, growth, differentiation and migration. The BioInk™ is suitable for long-term tissue c*tion (in vitro human dermis for up to 7 weeks).

Modular Matrix Tailored to the needs of your cells
Combined with BioFactory™ or 3DDiscovery™ tissue printers, you will be able to create composite tissue models in a layer-by-layer fashioning with spatial control of bioactive components (matrix, cells, proteins) and biomaterials.

BioInk Datasheet

STARK™

3D SHAPE FIDELITY FOR BIOMIMICS | BIOPOLYMER FOR SCAFFOLDING SUPPORT

Creation of tissue models of complex bioarchitectures and overhanging structures, in single or composite materials, may require fugitive support materials that act as a temporary scaffold for the structure.

Especially in 3D cell culture & LifeScience applications where extracellular matrix materials (ECM) such as low-viscose hydrogels, collagens or similar are used to encapsulate and deliver bioactives, STARK™ biopolymer enables 3D shape fidelity and bioarchitecture control of cell-laden conceptions.

STARK™ is a biocompatible biopolymer dedicated to hard & soft tissue engineering with either a 3DDiscovery™ or BioFactory™ bioprinting platform. It can be used during the construction process in combination with BioInk™ or OsteoInk™ or any natural or synthetic printable biomaterials.

FACTS

• Designed for 3DDiscovery™ & BioFactory™ bioprinters
• Cell friendly biocompatible support material, flexible/soft and controlled hardening
• For Research & Development
• Thermosensitive cross-linking
• Can be combined with any printable biomaterial in single process approach
• Exploit full potential with Bioprinting Software Suite (BioCAM™, BioCUT™)
• Available in 3cc cartridges, ready to use single component cartridge