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標(biāo)準(zhǔn)品裸藻毒素PbTX-1/Brevetoxin A，PbTX-1

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公司名稱(chēng) 廣州市齊云生物技術(shù)有限公司
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裸藻毒素PbTX-1/Brevetoxin A PbTX-1

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裸藻毒素PbTX-1/Brevetoxin A，PbTX-1

Source:	Eupenicillium brefeldianum
Synonyms	Ascotoxin, Cyanein, Decumbin
Description:	A macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity.
CAS number:	20350-15-6
Merck index:	11, 1363
Molecular weight:	280.4
Structure:
Molecular Formula:	C₁₆H₂₄O₄
Solubility information:	Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate
Specifications
Appearance:	White to off-white crystalline solid.
Purity:	At least 98% by TLC
λ_max:
Melting point	198°C-205°C
Solubility	Clear colorless solution at 10mg/ml Dichloromethane. Clear colorless solution at 10mg/ml Methanol.
Storage	-20°C
Applications	Inhibitor of protein translocation from endoplasmic reticulum （ER） to the Golgi apparatus. Inhibitor of intracellular protein transport and protein secretion
Warnings	TOXIC
Classification	macrocyclic lactone antibiotic. Antifungal Antiviral Protein Synthesis Inhibitor
Related products
	For Research use only. Not for Human or Drug use GMP/API grade available on request No genetically modified organisms are used.
Publications
	Khine AA, Tam P, Nutikka A, Lingwood CA. Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity. Glycobiology. 2004 Apr 21
	Salles FT, Hespanhol AM, Jaeger RG, Marques MM. Brefeldin-A induces apoptosis in human adenoid cystic carcinoma cultured cells. Oral Oncol. 2004 Jul;40（6）:585-90.
	Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M. Nuclear localization and molecular partners of BIG1, a brefeldin A -inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. Proc Natl Acad Sci U S A. 2004 Mar 2;101（9）:2752-7.
	Mossessova E, Corpina RA, Goldberg J. Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mol Cell. 2003 Dec;12（6）:1403-11.
	Togawa A, Ito H, Kimura F, Shimizu H, Ohtsuka M, Shimamura F, Yoshidome H, Katoh A, Miyazaki M. Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of Brefeldin-A on the resistant cell line. Pancreas. 2003 Oct;27（3）:220-4.
	Vetterlein M, Niapir M, Ellinger A, Neumuller J, Pavelka M. Brefeldin A regulated retrograde transport into the endoplasmic reticulum of internalised wheat germ agglutinin. Histochem Cell Biol. 2003 Aug;120（2）:121-8.
	Lee MJ, Park JY, Lee SY, Lee JS, Jung DK, Bae YS, Kwak JY. Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils. Int Immunopharmacol. 2003 Jun;3（6）:835-43.
	Campenot RB, Soin J, Blacker M, Lund K, Eng H, MacInnis BL. Block of slow axonal transport and axonal growth by brefeldin A in compartmented cultures of rat sympathetic neurons. Neuropharmacology. 2003 Jun;44（8）:1107-17.
	Pommepuy I, Terro F, Petit B, Trimoreau F, Bellet V, Robert S, Hugon J, Labrousse F, Yardin C. Brefeldin A induces apoptosis and cell cycle blockade in glioblastoma cell lines. Oncology. 2003;64（4）:459-67.
	Edward_B_Neufeld , Adele M. Cooney , Josef Pitha, Eliezar A. Dawidowicz , Nancy K. Dwyer, Peter G. Pentchev, E. Joan Blanchette-Mackie Brefeldin A applications: Intracellular Trafficking of Cholesterol Monitored with a Cyclodextrin BJU International, Volume 271, Number 35, Issue of August 30, 1996 pp. 21604-21613

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標(biāo)準(zhǔn)品 裸藻毒素PbTX-1/Brevetoxin A，PbTX-1

公司介紹主營(yíng)產(chǎn)品

詳細(xì)信息 在線(xiàn)詢(xún)價(jià)

裸藻毒素PbTX-1/Brevetoxin A，PbTX-1

Source:

Eupenicillium brefeldianum

Synonyms

Ascotoxin, Cyanein, Decumbin

Description:

A macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity.

CAS number:

20350-15-6

Merck index:

11, 1363

Molecular weight:

280.4

Structure:

Molecular Formula:

C16H24O4

Solubility information:

Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate

Specifications

Appearance:

White to off-white crystalline solid.

Purity:

At least 98% by TLC

λmax:

Melting point

198°C-205°C

Solubility

Clear colorless solution at 10mg/ml Dichloromethane. Clear colorless solution at 10mg/ml Methanol.

Storage

-20°C

Applications

Inhibitor of protein translocation from endoplasmic reticulum （ER） to the Golgi apparatus. Inhibitor of intracellular protein transport and protein secretion

Warnings

TOXIC

Classification

macrocyclic lactone antibiotic. Antifungal Antiviral Protein Synthesis Inhibitor

Related products

For Research use only. Not for Human or Drug use GMP/API grade available on request No genetically modified organisms are used.

Publications

Khine AA, Tam P, Nutikka A, Lingwood CA. Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity. Glycobiology. 2004 Apr 21

Salles FT, Hespanhol AM, Jaeger RG, Marques MM. Brefeldin-A induces apoptosis in human adenoid cystic carcinoma cultured cells. Oral Oncol. 2004 Jul;40（6）:585-90.

Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M. Nuclear localization and molecular partners of BIG1, a brefeldin A -inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. Proc Natl Acad Sci U S A. 2004 Mar 2;101（9）:2752-7.

Mossessova E, Corpina RA, Goldberg J. Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism. Mol Cell. 2003 Dec;12（6）:1403-11.

Togawa A, Ito H, Kimura F, Shimizu H, Ohtsuka M, Shimamura F, Yoshidome H, Katoh A, Miyazaki M. Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of Brefeldin-A on the resistant cell line. Pancreas. 2003 Oct;27（3）:220-4.

Vetterlein M, Niapir M, Ellinger A, Neumuller J, Pavelka M. Brefeldin A regulated retrograde transport into the endoplasmic reticulum of internalised wheat germ agglutinin. Histochem Cell Biol. 2003 Aug;120（2）:121-8.

Lee MJ, Park JY, Lee SY, Lee JS, Jung DK, Bae YS, Kwak JY. Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils. Int Immunopharmacol. 2003 Jun;3（6）:835-43.

Campenot RB, Soin J, Blacker M, Lund K, Eng H, MacInnis BL. Block of slow axonal transport and axonal growth by brefeldin A in compartmented cultures of rat sympathetic neurons. Neuropharmacology. 2003 Jun;44（8）:1107-17.

Pommepuy I, Terro F, Petit B, Trimoreau F, Bellet V, Robert S, Hugon J, Labrousse F, Yardin C. Brefeldin A induces apoptosis and cell cycle blockade in glioblastoma cell lines. Oncology. 2003;64（4）:459-67.

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標(biāo)準(zhǔn)品裸藻毒素PbTX-1/Brevetoxin A，PbTX-1

詳細(xì)信息在線(xiàn)詢(xún)價(jià)

C₁₆H₂₄O₄

Solubility
information:

λ_max:

Clear colorless solution at 10mg/ml Dichloromethane.
Clear colorless solution at 10mg/ml Methanol.

macrocyclic lactone antibiotic.
Antifungal
Antiviral
Protein Synthesis Inhibitor

For Research use only. Not for Human or Drug use
GMP/API grade available on request

No genetically modified organisms are used.

Khine AA, Tam P, Nutikka A, Lingwood CA.
Brefeldin A and filipin distinguish two globotriaosyl ceramide/verotoxin-1 intracellular trafficking pathways involved in Vero cell cytotoxicity.
Glycobiology. 2004 Apr 21

Salles FT, Hespanhol AM, Jaeger RG, Marques MM.
Brefeldin-A induces apoptosis in human adenoid cystic carcinoma cultured cells.
Oral Oncol. 2004 Jul;40（6）:585-90.

Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M.
Nuclear localization and molecular partners of BIG1, a brefeldin A -inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors.
Proc Natl Acad Sci U S A. 2004 Mar 2;101（9）:2752-7.

Mossessova E, Corpina RA, Goldberg J.
Crystal structure of ARF1*Sec7 complexed with Brefeldin A and its implications for the guanine nucleotide exchange mechanism.
Mol Cell. 2003 Dec;12（6）:1403-11.

Togawa A, Ito H, Kimura F, Shimizu H, Ohtsuka M, Shimamura F, Yoshidome H, Katoh A, Miyazaki M.
Establishment of gemcitabine-resistant human pancreatic cancer cells and effect of Brefeldin-A on the resistant cell line.
Pancreas. 2003 Oct;27（3）:220-4.

Vetterlein M, Niapir M, Ellinger A, Neumuller J, Pavelka M.
Brefeldin A regulated retrograde transport into the endoplasmic reticulum of internalised wheat germ agglutinin.
Histochem Cell Biol. 2003 Aug;120（2）:121-8.

Lee MJ, Park JY, Lee SY, Lee JS, Jung DK, Bae YS, Kwak JY.
Modulation of constitutive and delayed apoptosis by brefeldin A in human neutrophils.
Int Immunopharmacol. 2003 Jun;3（6）:835-43.

Campenot RB, Soin J, Blacker M, Lund K, Eng H, MacInnis BL.
Block of slow axonal transport and axonal growth by brefeldin A in compartmented cultures of rat sympathetic neurons.
Neuropharmacology. 2003 Jun;44（8）:1107-17.

Pommepuy I, Terro F, Petit B, Trimoreau F, Bellet V, Robert S, Hugon J, Labrousse F, Yardin C.
Brefeldin A induces apoptosis and cell cycle blockade in glioblastoma cell lines.
Oncology. 2003;64（4）:459-67.